Alzheimer’s Disease / Lewy Body Dementia

FACTS

  • both characterized by a cholinergic deficiency
  • pathology: tau neurofibrillary tangles
    • may co-occur with cerebral amyloid angiopathy
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AD
LBD
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HPI

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AD
LBD
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1. fluctuating cognition
2. Parkinsonism
3. visual hallucinations

PHYSICAL EXAM

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AD
LBD
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IMAGING

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AD
LBD
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A/P
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AD
LBD
Medical treatment
cholinesterase inhibitors
nicotinic agonists
muscarinic agonists
NMDA antagonists
cholinesterase inhibitors
nicotinic agonists
muscarinic agonists
Notes
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Avoid first-generation antispychotics (worsen parkinsonism, can cause NMS)